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We employed a method that has been reported to measure conformational changes in cell surface receptors, namely trFRET, to investigate the impact of ITP on the conformation of the N-terminal SNAP-tagged version of the IR (Fig

The accumulation of ROS is particularly detrimental in cardiac tissues, where it can disrupt calcium homeostasis, contributing to cardiac dysfunction and arrhythmias (79)

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Ferroptosis is induced by disruption of glutathione synthesis or inhibition of glutathione peroxidase 4, exacerbated by iron, and prevented by radical scavengers such as ferrostatin-1, liproxstatin-1, and endogenous vitamin E